Download The Pathology of the Endocrine Pancreas in Diabetes by P. J. Lefèbvre (auth.), Professor Dr. Pierre J. Lefèbvre, PDF
By P. J. Lefèbvre (auth.), Professor Dr. Pierre J. Lefèbvre, Professor Dr. Daniel G. Pipeleers (eds.)
Diabetes mellitus represents some of the most widespread and severe scientific syn dromes in modern drugs. because the finish of the 19th century, the endocrine pancreas has been implicated within the pathogenesis of this ailment. numerous pathologists of the 20 th century detected a number of lesions and mor phologic changes within the pancreatic islets of diabetic sufferers, however the patho physiologic foundation in their findings remained lengthy vague. The systematic mi croscopic paintings of WILLY GEPTS clarified the perspectives and similar the diversity in histopathology to ameliorations in beginning, length and scientific expression of the disorder. over the last twenty years, the idea that of a multifactorial beginning of diabetes has develop into largely approved. quite a few brokers and mechanisms were pointed out which may end up in a quantitative or qualitative deficit in pancre atic B-cells. the aim of this ebook is to carry an replace at the many direction methods which can result in an absolute or relative insufficiency in insulin free up and accordingly a diabetic country. instead of bringing a whole account on all re seek suitable to the certainty of the pathology of the diabetic pancreas, the authors of a number of the chapters of this quantity have focussed on chosen methods which may impair B-cell functionality, survival or regeneration.
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Diabetes mellitus represents essentially the most widespread and severe scientific syn dromes in modern drugs. because the finish of the 19th century, the endocrine pancreas has been implicated within the pathogenesis of this sickness. numerous pathologists of the 20th century detected quite a few lesions and mor phologic changes within the pancreatic islets of diabetic sufferers, however the patho physiologic foundation in their findings remained lengthy imprecise.
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Extra resources for The Pathology of the Endocrine Pancreas in Diabetes
Type 2 Diabetes Macroscopy The gross appearance of the pancreas is little affected in type 2 diabetes. In our series the mean weight of the pancreas was only slightly reduced but in control series important variations were observed . The relative weight of the lobe rich in PP-cells was, however, significantly increased, reaching 15% of the whole gland versus 10% in healthy individuals. KLOPPEL has recently shown that the weight of the pancreas is higher in obese than in nonobese patients, whether they are diabetic or not .
This atrophy is probably the morphological consequence of the disappearance of insulin, which is known to exert a trophic effect on the exocrine pancreas [1, 72, 94] as recently confirmed by experimental data . Histological Appearance of the Islets Type 1 Diabetes of Recent Onset LECOMPTE , GEPTS , DONIACH and MORGAN , and JUNKER et al.  analyzed the morphology of the diabetic pancreas in the initial period of the disease. Their observations are invaluable, since the more recent advances in early diagno- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The Diabetic Pancreas: A Pathologist's View 23 sis and treatment have made this type of material very rare.
References 1. Adler G, Kern HF (1975) Regulation of exocrine pancreatic secretory process by insulin in vivo. Horm Metabol Res 7: 290-296 2. Alumets J, Hakanson R, Lundqvist G, Sundler F, Thorell J (1980) Ontogeny and ultrastructure of somatostatin and calcitonin cells in the thyroid gland of the rat. Cell Tissue Res 206: 193-201 3. Banting FG, Best CH (1922) The internal secretion of the pancreas. J Lab Clin Med 7: 251-266 4. Bartow SA, Mukai K, Rosai J (1981) Pseudoneoplastic proliferation of endocrine cells in pancreatic fibrosis.