By Youn B.-S., Kwon B.S.
CDNA for 2 new participants of the human CC chemokine kin was once remoted according to structuraland sensible similarities to leukotactin 1 (Lkn-1). this sort of cDNA clones was once similar to the formerly remoted CC chemokine, CK♀8 (MPIF1), while the opposite is an enormous splicing variation, as a result named CK♀8-1. The mature proteins of CK♀8-1 and CK♀8 consisted of 116 and ninety nine amino acids with calculated molecular weights of 12,500 and 10,950, respectively. either CK♀8-1 and CK♀8 have been effective agonists for CCR1. those chemokines prompted migration of neutrophils, monocytes, and lymphocytes, which is analogous to Lkn-1. additionally they considerably suppressed colony formation by means of human bone marrow, granulocyte-macrophage, erythroid, and multipotential progenitor cells influenced via combos of progress elements. Lkn-1 and CK♀8-1 gene have been mapped to a similar bacterial synthetic chromosome. To our wisdom, this is often the 1st instance displaying that an alternate splicing produces lively CC chemokines from a unmarried gene.