Download Cancer Drug Resistance (Cancer Drug Discovery and by Beverly A. Teicher PDF

By Beverly A. Teicher

Major specialists summarize and synthesize the most recent discoveries about the alterations that take place in tumor cells as they increase resistance to anticancer medicines, and recommend new ways to fighting and overcoming it. The authors evaluate physiological resistance dependent upon tumor structure, mobile resistance according to drug delivery, epigenetic alterations that neutralize or skip drug cytotoxicity, and genetic alterations that modify drug goal molecules via lowering or removing drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic remedies, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the advance of more beneficial treatments. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Show description

Read or Download Cancer Drug Resistance (Cancer Drug Discovery and Development) PDF

Similar anatomy books

Langman's Medical Embriology

Supplying remarkable complete colour diagrams and scientific photographs, Langman's clinical Embryology, 13e is helping scientific, nursing, and wellbeing and fitness professions scholars boost a easy knowing of embryology and its scientific relevance. Concise bankruptcy summaries, desirable scientific correlates bins, medical difficulties, and a transparent, concise writing variety make the subject material obtainable to scholars and correct to teachers.

Transduction Channels in Sensory Cells

This is often the 1st e-book to supply a molecular point clarification of the way the senses paintings, linking molecular biology with sensory body structure to infer the molecular mechanism of a key step in sensory sign new release. The editors have assembled specialist authors from all fields of sensory body structure for an authoritative assessment of the mechanisms of sensory sign transduction in either animals and crops.

Get Ready for A&P (Anatomy and Physiology)

Key profit: to be had as a workbook and web site, this source saves school room time and frustration by means of helping readers fast arrange for his or her A&P path. The hands-on workbook gets readers in control with simple research talents, math talents, anatomical terminology, simple chemistry, phone biology, and different fundamentals of the human physique.

Extra resources for Cancer Drug Resistance (Cancer Drug Discovery and Development)

Sample text

Wilkinson-Berka JL. Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. Curr Pharm Des 2004; 10:3331–3348. 3. Folkman J, Hanahan D. Switch to the angiogenic phenotype during tumorigenesis. Princess Takamatsu Symp 1991; 22:339–347. 4. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721–732. 5. Rak J, Mitsuhashi Y, Bayko L, et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

TUMOR PH It has long been known that the microenvironment in tumors of both animal and human is acidic as compared with that in normal tissues because of elevated in anaerobic as well as aerobic glycolysis in tumors (1–6). As tumor nodules are formed, neovascularization begins from host venules stimulated by a number of angiogenic factors secreted by the tumor cells as well as adjacent normal cells. The newly formed tumor vascular beds are characterized by a heterogeneous distribution of dilated, irregularly bulged, constricted, twisted, and sharply bent capillary-like blood vessels (14–23).

Three types of ATPdriven H+ pumps have also been identified (57). One of these is an ATPase-linked H+ pump found in some specialized epithelial cells. It has been reported that one of the mechanisms to maintain the cytosolic pH at physiological level is sequestration of cytosolic protons into acidic cellular vesicles such as endoplasmic reticulum, endosomes, and lysosomes. Interestingly, the ATPase-linked H+ pump has been identified in a number of intracellular organelles, indicating that the ATPase-linked H+ pump plays an important role in regulating pH in the vesicles and cytosol.

Download PDF sample

Rated 4.65 of 5 – based on 6 votes