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By W. J. Mooi MD, T. Krausz MD, MRCPath (auth.)

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And Hashimoto, K. (1987) The differential reactivity of benign and malignant nevomelanocytic lesions with mouse monoclonal antibody TNKHl. Cancer, 59, 1340-4. Natali, P. , Veglia, F. et al. (1983) The impact of monoclonal antibodies on the study of human malignant melanoma. J. Cutan. , 10, 514-28. Ordonez, N. , Xiaolong, J. and Hichey, R. C. (1988) Comparison of HMB-45 monoclonal antibody and S-100 protein in the immunohistochemical diagnosis of melanoma. Am. J. Clin. , 90, 385-90. Palazzo, J. and Duray, P.

113). It is easily distinguished from melanin since it is birefringent and does not stain with the silver stains for melanin (Ackerman and Penneys, 1970). Formalin pigment can be rapidly dissolved by incubation of the slide in a picric acid solution. 5% potassium permanganate solution, or a variety of other chemicals. After bleaching with potassium permanganate, the slides remain suitable for immunohistochemistry (McGovern and Crocker, 1987). , 1979). In addition, an intense autofluorescence of melanoma cells and weak fluorescence of some naevus cells in unstained paraffin sections of formalin-fixed specimens can be found (Inoshita Tissue processing and staining methods 23 and Youngberg, 1982); this is not due to the presence of melanin pigment.

2 Ephelis Clinical features Small light-brown macules, usually multiple Occur in sun-exposed areas of the skin and arise or become more pronounced after increased exposure to sunlight (summer) Occur mainly in light-skinned people with blonde or reddish hair Histological features Mild hyperpigmentation of basal epidermal keratinocytes Slight prominence but no increased number of melanocytes Normal epidermal architecture, no elongation of rete ridges Occasional melanophages in upper dermis. 3 Solar lentigo (senile lentigo; 'liver spot') Solar lentigo is a small, darkly pigmented macule, occurring on chronically sun-exposed skin, usually in elderly persons.

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