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In Europe, high-flux dialysis and HDF are used as treatment modalities for chronic renal failure. Conventional HDF utilizes large convective transport with ultrafiltration rates above 70 ml/min. Since the ultrafiltration rate exceeds the rate of desired weight loss in the patient, sterile replacement fluid must be administered. The net ultrafiltration rate in the patient will be equal to the difference between total ultrafiltration rate and reinfusion rate. Total ultrafiltration varies between 12 and 15 l/session.

1). The membrane represented by curve A has a large number of relatively small pores while the membrane represented by curve B has a large number of relatively large pores. Based on the relatively narrow pore size distributions, the solute sieving coefficient versus molecular weight profile for both membranes has the desirable sharp cut-off, similar to that of the native kidney. However, the molecular-weight cut-off for membrane A (approx. 10 kDa) is consistent with a high-efficiency membrane while that of membrane B (approx.

In a recent clinical evaluation, Ronco et al. [28] measured the effect of ‘microcrimping’ and spacer yarns on both small-solute removal and dialysate Clark/Rocha/Ronco 30 Standard Space yarns Moiré structure Fig. 4. Dialysate flow distribution in dialyzers having different structures. ) Reprinted with permission from Ronco et al. [28]. flow distribution. The microcrimped fibers contained in the dialyzers used in this study have a relatively low amplitude and high frequency. e. fibers with standard undulation and no spacer yarns), urea clearances were found to be significantly higher for dialyzers with both microcrimped fibers and spacer yarns.

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