Download A Short History of the Drug Receptor Concept (Science, by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis PDF

By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell

The receptor thought was once the most influential rules in 20th-century drugs since it may well account for the hugely particular results of gear at the physique. This e-book is the 1st to supply an old dialogue of its foundation, improvement, gradual attractiveness into pharmacology and next influence on smooth medication. It additionally considers the social context that inspired the drug receptor's development., creating a invaluable contribution to the background and figuring out of contemporary drugs.

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Moreover, the antagonism between the two poisons could be demonstrated locally, by way of direct application, in different parts of the heart. 6 In this way Langley’s work on jaborandi provided supporting evidence for Foster’s view that the heartbeat had a muscular, not a nervous origin. Yet, this was not its only significance. At the very start of his career, Langley had hit upon a problem that would recur again and again in the course of his experimental work and that ultimately led him to his theory of receptive substances: do drugs act directly on the effector cells (in this case, the heart cells) or do they primarily affect the endings of nerves terminating in the organ tissues?

The young Langley was especially attracted by Foster’s classes in elementary biology, embryology and physiology. Foster, who had been appointed as praelector of physiology at Trinity College in 1870, held to the principle of providing his students from early on with the opportunity to acquire first-hand knowledge through their own experimental work in his physiological laboratory, in those days a single room that was also used for lectures. Even before Langley graduated with a BA in 1875, Foster had involved him in his research programme.

Ehrlich repeatedly asked them to test his substances. Even if the clinicians were prepared, in principal, to undertake the experiments, Ehrlich had to press them forcefully to do the test and to report the results. The system did not work well and from June 1899 at the latest Ehrlich showed signs of frustration. 140 In the end, dye testing appears to have been a futile attempt to restore the old Charité conditions, where laboratory work and animal experimentation could be linked with clinical expertise.

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